Effects last for six-to-eight hours (immediate release formulations) or twelve hours (extended-release formulations). BMJ 302 Antivert (meclizine)." Minor Potential Hazard, Low plausibility. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Anaesthesia 31 Benadryl (diphenhydramine)." Separate administration (take hyoscyamine an hour before or two hours after antacids). Hyoscyamine is used to treat a variety of stomach /intestinal problems such as cramps and irritable bowel syndrome. Merck & Co, Inc, West Point, PA. "Product Information. The half-life of hyoscyamine sulfate is 2 to 3 1/2 hours. Levsin (hyoscyamine) is classified as an anticholinergic-sedative. Blurred vision, constipation, dizziness, drowsiness, dry mouth, flushing, headache, increased sensitivity to light, and problems with urination are the main side effects reported. Anticholinergics may further suppress intestinal motility with resultant precipitation or aggravation of toxic megacolon. (1979): 476-90. Applies to: Liver Disease. View complete list of side effects. How it works. (1986): 571, Stadnyk AN, Glezos JD "Drug-induced heat stroke." Antimuscarinic agents decrease gastric motility and relax the lower esophageal sphincter which promotes gastric retention and can aggravate reflux. The drugs are used to treat myasthenia gravis. (1985): 558-60. Hyoscyamine (Levsin) Dose in the treatment of Gastrointestinal disorders: Oral: Tablet, dispersible: Anaspaz, ED-SPAZ, NuLev: 0.125 to 0.25 mg every 4 hours or as needed; maximum: 1.5 mg/day ; Oscimin: 0.125 to 0.25 mg 3 to 4 times daily; may increase to every 4 hours as needed; maximum: 1.5 mg/day; Tablet, extended-release: Levbid: 0.375 to 0.75 mg every 12 hours; maximum: … Anesthesiology 39 Hyoscyamine may also interact with some medications including antidepressants and antipsychotics. (1982): 196-200, Massumi RA, Mason DT, Amsterdam EA, DeMaria A, Miller RR, Scheinman MM, Zelis R "Ventricular fibrillation and tachycardia after intravenous atropine for treatment of bradycardias." (1992): 880, Shutt LE, Bowes JB "Atropine and hyoscine." Obstet Gynecol 51 Ann Ophthalmol 6 However, ipratropium does not produce these effects and can be used safely in treating asthma. Merck & Co, Inc, West Point, PA. "Product Information. May cause drowsiness and affect your ability to drive or operate machinery. Diarrhea may be a symptom of incomplete intestinal obstruction, especially in patients with ileostomy or colostomy. Artane (trihexyphenidyl)." Cogentin (benztropine)." Can Anaesth Soc J 24 Premature ventricular depolarization or ventricular tachycardia or fibrillation associated with anticholinergics is rare. liver or kidney disease; heart problems; or; breathing problems. Pacing Clin Electrophysiol 5 (1977): 677. Optimine (azatadine)." Revised 10/2019. (1992): 564. Bantz EW, Dolen WK, Chadwick EW, Nelson HS "Chronic chlorpheniramine therapy: subsensitivity, drug metabolism, and compliance." Anticholinergics are contraindicated in patients with obstructive diseases such as achalasia, esophageal stricture or stenosis, pyloroduodenal stenosis, stenosing peptic ulcer, pyloric obstruction, and paralytic ileus. Last updated on Jun 10, 2020. Take with food. Minor Potential Hazard, Moderate plausibility. "Harrison's Principles of Internal Medicine. May be used to treat bladder spasms, colic, diverticulitis, irritable bowel syndrome, pancreatitis, and peptic ulcer disease. Some cough and cold and other combination products may occasionally include antimuscarinic agents for their drying effects and may, therefore, require careful selection when necessary. It is also used to treat other conditions such as bladder and bowel control problems, cramping pain caused by kidney stones and gallstones, and Parkinson's disease. Hyoscyamine is also used in the treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, and irritable bowel syndrome. "Product Information. Gate Pharmaceuticals, Sellersville, PA. "Product Information. Caution is advised even when using agents with mild to moderate anticholinergic activity, particularly in elderly patients. antacids, such as aluminum hydroxide or magnesium hydroxide, antidepressants, such as amitriptyline, clomipramine, desipramine, doxepin, imipramine, nortriptyline, phenelzine, or tranylcypromine, antihistamines, such as diphenhydramine or promethazine, antipsychotics, such as chlorpromazine, fluphenazine, haloperidol, perphenazine, risperidone, thioridazine, trazodone, trifluoperazine, medicines that affect gastrointestinal motility, such as pramlintide. Clin Pediatr (Phila) 24 (1971): 13-34. Because antimuscarinic agents have anticholinergic effects, they are contraindicated in patients with myasthenia gravis. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. "Product Information. ESI Lederle Generics, Philadelphia, PA. "Product Information. Am J Ophthalmol 99 These drugs may prolong and/or worsen diarrhea associated with organisms that invade the intestinal mucosa, such as toxigenic E. coli, Salmonella and Shigella, and pseudomembranous colitis due to broad-spectrum antibiotics. Major Potential Hazard, Moderate plausibility. Applies to: Gastroesophageal Reflux Disease. Hyoscyamine is sometimes used to reduce tremors and rigid muscles in people with symptoms of Parkinson's disease. Kidney disease does not tend to cause symptoms when it's at an early stage. We comply with the HONcode standard for trustworthy health information -, Drug class: anticholinergics/antispasmodics. Because anticholinergics cause mydriasis, they may exacerbate these conditions. New York, NY: McGraw-Hill Health Professionals Division Antacids may interfere with hyoscyamine, reducing its effectiveness. "Product Information. Roerig Division, New York, NY. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. ( 1991 ): 957-9, Forester D '' Fatal Drug-induced heat stroke. (... During myocardial infarction imaging studies imaging studies by blocking the action of acetylcholine in the urine (... Lamminsivu U, Ottoila P `` Pharmacokinetics of methenamine in healthy volunteers. that! Usually avoid combinations ; use it only under special circumstances effect on the gastro-oesophageal sphincter in man. common of... Extraintestinal illness may also be increased or prolonged Loperamide related toxic megacolon also as. Increased thickening of secretions list of interactions Anaesth Soc J 24 ( )! 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