[6] It is also a component in brake fluid, lubricants, wallpaper strippers, artificial fog and haze solutions, and heating/cooking fuel. Because patients treated with Lisinopril developed a cough (a common side effect of ACE inhibitors), they were prescribed an expectorant. Diethylene Glycol Monobutyl Ether exposure symptoms, causes, diagnosis, and treatment information for Diethylene Glycol Monobutyl Ether exposure (Chemical poisoning - Diethylene Glycol Monobutyl Ether) with alternative diagnoses, full-text book chapters, misdiagnosis, research … • As a cosurfactant in the formation of microemulsions. [42] In Spain, Rasfer International declared bankruptcy after the lawyer of Medicom filed a lawsuit of $400 million in July 2008. A wide variety of diethylene glycol monobutyl ether options are available to you, such as classification, grade standard, and usage. When 105 people died in 15 states during the months of September and October, the trail led back to the elixir, and the toxic potential of this chemical was revealed. [11] The major cause of ethylene glycol toxicity is the accumulation of glycolic acid in the body,[12] but the accumulation of calcium oxalate crystals in the kidneys can also lead to acute kidney failure. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. 2-(2-Ethoxyethoxy)ethanol (IUPAC) Diethylene Glycol Monoethyl Ether. [2] It can be a contaminant in consumer products; this has resulted in numerous epidemics of poisoning since the early 20th century. The children later developed kidney failure and died. Lead CDC investigator Dr. Katherine O'Brien conducted a case-control investigation, looking for potential clues to the epidemic. [64][65][66], In December 2019, some people in the city of Belo Horizonte, initially all from the same neighbourhood, started having symptoms such as nausea, vomiting, abdominal pain, acute kidney failure, facial nerve paralysis, blurred vision, temporary blindness and sensory changes. Industry Circular No. The primary results revealed that the mixture was more effective than using salt alone. Glycol ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. [1] In personal care products (e.g. Unique Ingredient Identifier. In fact, the company bought the product in China and had already re-exported toothpaste to Costa Rica, Dominican Republic and Haiti, making Panama kick off a local warning. Mr. Wang was caught and Qiquihar was shut down by the authorities. Rat models suggest DEG is metabolized in the liver by enzyme NAD-dependent alcohol dehydrogenase (ADH) into a hydrogen ion, NADH and 2-hydroxyethoxyacetaldehyde (C4H8O3). 17 November 2016. Wang declared that after making the first order of counterfeit syrup, he swallowed some of it. The product was recalled and after an investigation, the Drug Controller General of India, VG Somani, said at India Pharma 2020, that the GMP was not followed, and negligence was found during the production process itself. [3], "Diethylene glycol is derived as a co-product with ethylene glycol (MEG) and triethylene glycol. All patients are likely to suffer significant morbidity. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. [44], The New York Times reported that Taixing was closed by the Chinese government and CNSC Fortune Way, which is also owned by the Chinese government, was never sanctioned. The regional drug controller authorities after investigation found out that a faulty batch of the Coldbest PC cough syrup contained 34.97% of diethylene glycol, which resulted in poisoning and subsequent renal failures. Jean-Claude Bradley Open Melting Point Dataset, NFPA 704: Standard System for the Identification of the Hazards of Materials for Emergency Response, InChI=1S/C8H18O3/c1-2-3-5-10-7-8-11-6-4-9/h9H,2-8H2,1H3, Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard, splash10-006t-9000000000-9b5ce4bf5bfa84239e88, splash10-03di-1900000000-8aef03e0bb456b96d1a4, splash10-03di-0900000000-3ac8a328666dee650638, splash10-0a4j-9000000000-44b0731c3639435643fb, https://www.wikidata.org/w/index.php?title=Q1018210&oldid=1314798026, Creative Commons Attribution-ShareAlike License. Diethylene glycol (DEG) is an organic compound with the formula (HOCH2CH2)2O. [39] Immediately, biological samples and the syrup were sent by jet to CDC for analysis. Depending on the conditions, varying amounts of DEG and related glycols are produced. O’Neil M. The Merck Index. DIETHYLENE GLYCOL MONOBUTYL ETHER 9TB90IYC0E Overview Structure Names 9: Classification 1: Identifiers 9: Relationships 1: Active Moiety 1: Audit Info References 15: Moieties 1: Substance Class: Chemical Record UNII: 9TB90IYC0E. Some wines contained less than 10 parts per million of DEG, a small amount that could not be detected by laboratory analysis in Europe. [3] Because of its adverse effects on humans, diethylene glycol is not allowed for use in food and drugs. English: Structure of Diethylene glycol monobutyl ether acetate. Nearly half of the victims were under the age of two. Doctors had no idea what was happening: the mysterious illness was attacking elderly citizens with hypertension and diabetes history. The industry generally operates to maximize MEG production. Diethylene glycol, monobutyl ether Ethyl Digol Glycol Ether DM ETHANOL, 2-(2-ETHOXYETHOXY)-DEGME. [29], The Panamanian Government made a nationwide campaign, collecting around 6,000 bottles of cough syrup and three other products with the tainted glycerin manufactured by Social Security Laboratories. Diethylene glycol monobutyl ether is used as a solvent in paints and varnishes e.g. They react with oxoacids and carboxylic acids to … Diethylene Glycol Monobutyl Ether Uses: This product is used primarily in the manufacturing of lacquers based on nitrocellulose, cellulose ethers and chlorinated rubber. [10], Diethylene glycol has moderate acute toxicity in animal experiments. The ether being relatively unreactive. • As a structural component of various liquid crystals. Fill out the form below and we will be in touch shortly. Packaging 1, 2.5 L in glass bottle "Austrian power plant to burn 'bad' wine. The resulting product is two ethylene glycol molecules joined by an ether bond. 121; Ethylne glycol butyl ether; Ethylene glycol monobutyl ether; Glycol butyl ether; Monobutyl glycol ether; 3-oxa-1-heptanol; EPA Pesticide Code: 011501 An unmitigated tragedy", "Epidemic of pediatric deaths from acute renal failure caused by diethylene glycol poisoning. [1] DEG is a widely used solvent. It is supplied as a urethane grade solvent. Synonyms and Related Terms. The outbreak forced the government to ban the sale of paracetamol elixirs in December 1992, causing a decline of 53% in the admission of patients with kidney failure and an 84% decline in admissions by unexplained kidney failure. Bogdanich, W. "Toxic Toothpaste Made in China Is Found in U.S. ". Hemodialysis might be administered alone or with ethanol or fomepizole. Jump to: navigation, search. While the FDA tried to find out Tianhong’s address, Chinese officials were reluctant to become involved. Packaging 1, 4 L in poly bottle 18 L in steel drum Legal Information Product of Dow Chemical language of work or name. The death rate of this mysterious illness was nearly 50%, when hospital management decided to isolate all the patients with the illness in a large room and doctors could compare notes and theories. [70] On 18 July, the 10th victim died in a Belo Horizonte hospital, a 65-year-old man who had been hospitalized since December 2019 due to the poisoning. Promotes uniform dispersion; translucent to clear. [1][19][28], During the summer months, 47 children were admitted to the Jos University teaching hospital, Nigeria, with anuria, fever and vomiting. [52], On June 1, 2007, the FDA warned consumers to avoid toothpaste from China, although there was no information if these toothpastes had already entered the US, and started testing any imported Chinese toothpaste. Glycols related to and coproduced with diethylene glycol and have the formula HOCH2CH2(OCH2CH2)nOH are: These compounds are all hydrophilic, more so than most diols, by virtue of the ether functionality. What began as a local alert revealed a global problem in more than 30 countries and involving more than thirty brands. It is a humectant for tobacco, cork, printing ink, and glue. The U.S. Code of Federal Regulations allows no more than 0.2% of diethylene glycol in polyethylene glycol when the latter is used as a food additive. Dermal absorption is very low, unless it is administered on broken or damaged skin. High boiling point. When urine analyses for a series of metals, pesticides or their metabolites resulted negative, CDC scientists recalled the Nigeria and Haiti incidents. Our team of experts are at the ready. 9TB90IYC0E. Description. After manufacturing a second batch of syrup containing diethylene glycol for Qiquhar Pharmaceutical, no taste-test was performed. The study revealed a strong association between ingestion of two locally produced acetaminophen liquid products (Afebril and Valodon) and illness. During the month of July 1985, Austrian wines were found to contain up to 1,000 parts per million of DEG, giving them a desirable sweetness. Both ethylene glycol and diethylene glycol are produced from same starting material; ethylene. Records also revealed that to fool buyers, Wang falsified his license and laboratory analysis reports. [57] It was later discovered that a great number of tubes with poison ended up in hospitals for the mentally ill, prisons, juvenile detention centers, other hospitals and many other state institutions. About half were receiving Lisinopril (a blood pressure medicine), and many did not remember clearly if they had been taking other drugs. After ingestion, DEG is absorbed through the gastrointestinal tract and distributed by the bloodstream throughout the body, reaching peak blood concentrations within 30 to 120 minutes. I, the copyright holder of this work, hereby publish it under the following licenses: All the children had received acetaminophen syrup to treat upper respiratory infections related with malaria. The CDC employed modern laboratory equipment to analyze the samples and confirm the results: the samples contained approximately 8% v/v DEG. [39] A New York Times reporter tried to obtain a comment from CNSC Fortune Way at the CPhI worldwide (the world’s largest annual pharmaceutical convention) held in Milan, Italy, during 2007, but their representatives refused to comment. They also arrested 12 people in connection with the incident. [39][41], Taixing sold the syrup as “TD glycerin”, wording that neither Chinese inspectors nor Spanish medical authorities comprehended. 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