Legal Category POM-V. Parasitol Res 112 Suppl 1, 57-66 PubMed. Advocate for cats contains 100 mg/ml imidacloprid and 10 mg/ml moxidectin. Do not exceed the recommended dose. cats. Directions for use: Use the top of the cap to break seal of tube. In this study, the efficacy and safety of a treatment with the combination imidacloprid 10 %/ moxidectin 1.0 % spot-on (Advocate(®) spot-on for small cats and ferrets) was tested in 39 ferrets naturally infested with ear mites (Otodectes cynotis). Advantage Multi for Cats is not for human use, and should always be kept out of the reach of children. Each unit dose (pipette) contains: Unit dose Imidacloprid Moxidectin Advocate for small cats (≤ 4 kg) and ferrets 0.4 ml 40 mg 4 mg Advocate for large cats (> 4–8 kg) 0.8 ml 80 mg 8 mg . Do not let animal lick treated area; keep other pets and children away from treated animals until the area has dried (about 30 The study was performed as a multicentre, non-random … For Kittens, Small Cats & Ferrets up to 4 kg . imidacloprid / moxidectin) An overview of Advocate and why it is authorised in the EU . The results of this study demonstrate that imidacloprid+moxidectin topical solution can be used safely in cats heavily infected with adult D. immitis. Cautions. Advantage Multi for cats 1% (10mg/mL) includes 10% Imidacloprid. The recommended minimum doses for cats are 10mg/kg body weight imidacloprid and 1.0mg/kg body weight moxidectin, equivalent to 0.1ml/kg body weight Endectrid for Cats. Imidacloprid attacks the nervous system in insects, which causes impairment and subsequently death. Resources. Part hair between the shoulder blades until skin is visible. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin based on body weight. For cats, the recommended minimum dose is 4.5 mg/lb. The recommended minimum dose is 10 milligrams per kilogram imidacloprid and 1 milligram per kilogram moxidectin once a month by topical administration. It will also treat and control whipworms in dogs and ear mites in cats. The active ingredients in Advantage Multi for Cats are Imidacloprid and Moxidectin . Administer the entire contents of the Advantage Multi ® for Cats tube that correctly corresponds with the body weight of the cat. (10.0 mg/kg) imidacloprid and 0.45 mg/lb. What is Advocate and what is it used for? There were no statistically significant differences in the comparison of adult D. immitis recovered at necropsy (ANOVA overall group effect P-value of 0.5356). Available in packs containing 3 and 6 pipettes of 0.4 and 0.8mL dose sizes.ActionImidacloprid exerts its effect by binding to post synaptic nicotinic receptors, blocking (1.0 mg/kg) moxidectin once a month by topical administration. Overview of Advantage Multi™ for Canines and Felines Imidacloprid and Moxidectin is a combination of drugs commonly known as Advantage Multi™. When used as directed on the label, imidacloprid with moxidectin is safe in most cats and ferrets. The recommended minimum doses are 10 mg/kg bodyweight imidacloprid and 1.0 mg/kg bodyweight moxidectin, equivalent to 0.1 ml/kg bodyweight Advocate for cats. Do not use on canaries. Common Precautions. Includes both imidacloprid (100g/L) and moxidectin (10g/L) : ... Moxiclear’s combination of Moxidectin and Imidacloprid has been shown to be safe in kittens when given from 9 weeks of age. This product may also be used monthly for prevention of heartworm infection and to treat flea infestations in ferrets. It is frequently used in combination with other medications to treat a variety of parasites. Weight of cat [kg] Pipette size to be used Volume [ml] Imidacloprid [mg/kg bw] Moxidectin [mg/kg bw] Moxiclear spot-on solution for large cats. Please refer to section 4.5. Two studies were conducted to evaluate and compare the efficacy of imidacloprid + moxidectin and selamectin topical solutions against the KS1 flea strain infesting cats. Each milliliter of constituted, sustained-release suspension contains 3.4 mg of moxidectin The formulation Advantage Multi for dogs 2.5% (25mg/mL) includes 25% Imidacloprid. Imidacloprid + moxidectin is applied between the shoulder blades every thirty days. Hellmann K, Petry G, Capari B, Cvejic D, Krämer F (2013) Treatment of naturally Notoedres cati-infested cats with a combination of imidacloprid 10 % / moxidectin 1 % spot-on (Advocate® / Advantage® Multi, Bayer). Advantage Multi ® for Cats (10% imidacloprid + 1% moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. METHODS: Cats were experimentally inoculated with 300-800 third-stage larvae (L3). The chemical name of imidacloprid is 1-[(6-Chloro-3-pyridinyl)methyl]-N-nitro-2-imidazolidinimine. A single treatment with this formulation also provided 88.4-100% control of adult C. felis for 35 days. This is a common over-the-counter medication used to prevent fleas and heartworms in dogs as well as ear mites in cats. Do not use on canaries. To compare the efficacy of two spot‐on treatments of moxidectin/imidacloprid, two weeks apart to a single oral dose of fluralaner against Lynxacarus radovskyi and evaluate time to re‐infestation. Excipients: Benzyl alcohol . CAUTION: Federal (U.S.A.) law restricts Advantage Multi® for Dogs to use by or on the order of a licensed veterinarian. The efficacy and safety of a combination formulation of 10% imidacloprid + 1.0% moxidectin spot-on (Advocate® for Cats, Bayer Animal Health GmbH, Leverkusen, Germany) was tested in 40 African pygmy hedgehogs (Atelerix albiventris) naturally infested with Caparinia tripilis. For dogs, the corresponding “Endectrid for dog” product, which contains 100 mg/ml imidacloprid and 25 mg/ml moxidectin, must be used. Dosage schedule for ferrets: one pipette of Advocate spot-on solution for small cats … Butylhydroxytoluene 1 mg/ml (E 321; as antioxidant). Advocate for Cats Over 4 kgActive ingredientsImidacloprid 100g/L and moxidectin 10g/L solution for topical application onto cats. Ferrets: Imidacloprid plus moxidectin for ferrets and is dosed according to weight. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. Each group comprised 8 animals and the treatment dose was 10 mg/kg bodyweight (bw) imidacloprid and 1 mg/kg bw moxidectin in each study. Background. Advantage Multi for Cats (10% imidacloprid + 1% moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. Active Ingredient IMIDACLOPRID: 100 mg/mL (= 10.0%) MOXIDECTIN: 25 mg/mL for dogs (= 2.5%) 10 mg/mL for cats (= 1.0%) CHEMICAL CLASS of the active ingredient(s): Imidacloprid: NEONICOTINOID; Moxidectin: MACROCYCLIC LACTONE Lynxacarus radovskyi has been observed in cats in Malaysia; previously treatment with fipronil and moxidectin/imidacloprid spot‐on has been described.. Cats: Imidacloprid plus moxidectin comes in 3 different sizes for cats and is dosed according to weight. The treatment schedule should be based on the local epidemiological situation. Imidacloprid and moxidectin is not recommended for animals that are nursing, pregnant, debilitated, or geriatric. The treatment schedule for all species should be based on individual veterinary diagnoses and on the local epidemiological situation. For dogs, the corresponding “Endectrid for dogs” product, which contains 100 mg/ml imidacloprid and 25 mg/ml moxidectin, must be used. 4.4 Special warnings for each target species. In this study, the efficacy and safety of a treatment with the combination imidacloprid 10 %/ moxidectin 1.0 % spot-on (Advocate® spot-on for small cats and ferrets) was tested in 39 ferrets naturally infested with ear mites (Otodectes cynotis). For Cats Over 4kg. Imidacloprid is a chloronicotinyl nitroguanidine insecticide. Each tube contains: IMIDACLOPRID & MOXIDECTIN. The recommended minimum doses for cats are 10 mg/kg body weight imidacloprid and 1.0 mg/kg body weight moxidectin, equivalent to 0.1ml/kg body weight Advocate for cats. Moxidectin also affects the nervous system in parasites and protects against heartworms. Advantage Multi® for Cats (10 % imidacloprid + 1 % moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. Imidacloprid is used on and off label and is applied topically to the skin to treat flea infestations. Side effects are uncommon but may include irritation at the application site, or, if the medication is accidentally ingested, drooling, shaking, vomiting, and decreased appetite. The formulation containing 10% imidacloprid and 1% moxidectin was 100% efficacious against the development of adult D. immitis infections when cats were treated 30 days after inoculation with third-stage larvae. Avoid any type of skin contact with the application site for 30 minutes following treatment with this topical flea medication. For ferrets: Do not use Endectrid for large cats (0.8 ml) or Endectrid for dogs (any size). Imidacloprid plus moxidectin (Advantage® Multi for Cats, Bayer) was used as a positive control in both studies at the label dosage. For ferrets: Do not use Endectrid for large cats (0.8 ml) or Endectrid for dogs (any size). Advantage Multi ® for Cats (10% imidacloprid + 1% moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin based on body weight. Place the tip of the tube on the skin and squeeze tube firmly to apply solution directly to the skin. General Description: Imidacloprid + moxidectin is a topical insecticide and endectocide agent used in dogs and cats once a month to treat and control fleas, heartworms, hookworms and roundworms. Please refer to section 4.5. Moxiclear is broad spectrum endectocide spot-on for very large cats (>4 ≤ 8 kg) containing imidacloprid and moxidectin. Objectives. 4.4 Special warnings for each target species. Advantage Multi® (imidaclopid + moxidectin) Discover how Advantage Multi® has an innovative transdermal formula with imidacloprid + moxidectin for monthly flea protection. Available in packs of 3 or 6 . Advantage Multi ® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. Advocate is a medicine used on cats, ferrets and dogs suffering from, or at risk from, mixed parasitic infections (caused by several different types of parasites): 10 % imidacloprid the chemical name of imidacloprid is 1- [ ( 6-Chloro-3-pyridinyl ) methyl ] -N-nitro-2-imidazolidinimine combination other... Multi® for dogs ( any size ) of the Advantage Multi for are! 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